The ultimate in compatibility for bioprocess manufacturing
Field of application
The Raman Rxn-45 probe capitalizes on the power of Raman in bioprocess manufacturing by measuring multiple, specific components in real-time for continuous, around-the-clock process feedback. It also meets the daunting sampling requirements of compliance, sterilization, port compatibility, and convenience. The Raman Rxn-45 probe was designed for installation in development and cGMP stainless-steel reactors and is successfully used to provide an analytical “eye” into large-scale bioprocesses.
Cell culture: glucose, lactate, amino acids, cell density, titer, and more
Fermentation: glucose, glycerol, acetate, methanol, ethanol, biomass, and more
Benefits
Measures multiple components in real-time for automated 24/7 process feedback
Provides long-term measurement stability
Offers a suitable surface finish for cGMP manufacturing
Provides compatibility with industry standard bioreactor side ports and sensor housings
Offers the flexibility of being installed in development and production reactors
Reduces sterilization and cleaning burdens with CIP/SIP standard compatibility
Specifications
Measuring principle
Raman spectroscopy
Spectral coverage
Probe spectral coverage is limited by the coverage of the analyzer being used.
Maximum laser power into probehead (mW)
< 499
Sample interface
Temperature: -30 to 150 °C / -22 to 302 °F Temperature ramp: ≤ 30 °C/min ≤ 54 °F/min
Pressure
Max pressure: 13.8 barg / 200 psig
Wetted materials
Body: 316L stainless steel Window: Proprietary material, optimized for bioprocesses Process connection: PG13.5 for industry standard sensor housings, welded port connectors available Surface finish: Ra 15 with electropolish Adhesive: USP Class VI and ISO993 compatible
Fiber optic cable
Cable sold separately
Length
120 mm / 4.73 inch
Diameter
12 mm / 0.48 inch
Sterilization method
CIP/SIP
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